Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model

Yiming Fu; Binh Minh Pham; Sicong He; Zhongya Qin; Ting Xie; Jianan Qu

doi:10.1117/12.2692203

12 March 2024 Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model

Yiming Fu, Binh Minh Pham, Sicong He, Zhongya Qin, Ting Xie, Jianan Qu

Author Affiliations +

Proceedings Volume 12824, Ophthalmic Technologies XXXIV; 128240H (2024) https://doi.org/10.1117/12.2692203
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

Glaucoma is characterized by the irreversible retinal ganglion cells (RGCs) loss and has received great research and clinical attention due to its complex mechanism and loss of effective treatment. Longitudinal in vivo study on glaucoma in mouse model can be a promising approach to unveil the mechanism of glaucoma. In this paper, we use a silicon oil (SO) induced glaucoma model on mouse and the adaptive optics two photon microscope system to evaluate whether the aberration from both mouse eye and SO can be corrected and then longitudinal imaging with subcellular resolution on the mouse retina can be achieved.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Yiming Fu, Binh Minh Pham, Sicong He, Zhongya Qin, Ting Xie, and Jianan Qu "Adaptive optics two photon microscopy enables in vivo longitudinal visualization of the glaucoma progression with subcellular resolution in the mouse model", Proc. SPIE 12824, Ophthalmic Technologies XXXIV, 128240H (12 March 2024); https://doi.org/10.1117/12.2692203

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available