Photoacoustic molecular imaging for microvascular system in browning adipose tissues

Ronghe Chen; Sangni Lixu; Tao Chen

doi:10.1117/12.2681769

18 July 2023 Photoacoustic molecular imaging for microvascular system in browning adipose tissues

Ronghe Chen, Sangni Lixu, Tao Chen

Proceedings Volume 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023); 127450L (2023) https://doi.org/10.1117/12.2681769
Event: Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 2023, Haikou, China

Abstract

At present, approximately one third of adults worldwide are obese or overweight. The phenomenon of adipose browning, that is, adipocyte trans-differentiation from an energy storage role to a heat production role, opens up a new way to reverse obesity. However, current methods for judging whether adipose browning occurs are usually based on invasive histological assessments. Adipose browning has been found to be accompanied by changes in adipose microvascular system. Therefore, our research focused on the above biological feature and used a non-invasive photoacoustic imaging technique that integrates the advantages of optical and acoustic imaging to visualize adipose microvascular system in obese mice treated with cold stimulation in a three-dimensional mode. The results showed that based on hemoglobin components, photoacoustic molecular imaging could not only accurately visually display a full view of increased arteriovenous blood network and enhanced blood oxygen consumption during adipose browning, but also quantitatively analyze it. Moreover, the data was consistent with the results of histological means including hematoxylin-eosin staining and immunofluorescence staining. In summary, we demonstrated the feasibility of photoacoustic molecular imaging for detecting adipose browning. This work will provide a new possibility for non-invasive assessment of adipose browning, which can help researchers and clinicians fight against obesity.

Citation Download Citation

Ronghe Chen, Sangni Lixu, and Tao Chen "Photoacoustic molecular imaging for microvascular system in browning adipose tissues", Proc. SPIE 12745, Sixteenth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2023), 127450L (18 July 2023); https://doi.org/10.1117/12.2681769

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
4 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Photoacoustic imaging

Adipose tissue

Photoacoustic spectroscopy

Imaging systems

Blood

Molecular imaging

3D image processing

Show All Keywords

Keywords/Phrases

Search In:

Publication Years