In vivo Raman spectroscopic study of suspected melanoma skin lesions and healthy skin

Di Wu; Anatoly Fedorov Kukk; Steffen Emmert; Bernhard Roth

doi:10.1117/12.2670621

11 August 2023 In vivo Raman spectroscopic study of suspected melanoma skin lesions and healthy skin

Di Wu, Anatoly Fedorov Kukk, Steffen Emmert, Bernhard Roth

Proceedings Volume 12627, Translational Biophotonics: Diagnostics and Therapeutics III; 1262704 (2023) https://doi.org/10.1117/12.2670621
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Cutaneous melanoma is one of the most lethal types of skin cancer. Non-invasively distinguishing malignant melanoma from benign tumours has always been a challenge. In this paper, an OCT and co-localized Raman spectroscopic system was built and Raman spectroscopy was used to measure skin samples of suspected melanoma lesions and their surrounding healthy areas non-invasively and in vivo. The Raman spectral signal intensities of the lesions increased at 1320 cm^-1 and 1650 cm^-1, while the content of carotenoids decreased, compared to that of the healthy skin samples. The results of the Shapley analysis values showed that the spectral peaks at 1320 cm^-1 and 1650 cm^-1 had a more significant effect on the differentiation of lesions from normal skin. This result can be used to guide the diagnosis of melanoma based on Raman spectroscopy.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Di Wu, Anatoly Fedorov Kukk, Steffen Emmert, and Bernhard Roth "In vivo Raman spectroscopic study of suspected melanoma skin lesions and healthy skin", Proc. SPIE 12627, Translational Biophotonics: Diagnostics and Therapeutics III, 1262704 (11 August 2023); https://doi.org/10.1117/12.2670621

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