Investigations on topologically associated domains from functional, evolutionary, and technical perspectives

Baoqin Fei

doi:10.1117/12.2669666

24 March 2023 Investigations on topologically associated domains from functional, evolutionary, and technical perspectives

Baoqin Fei

Author Affiliations +

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126113J (2023) https://doi.org/10.1117/12.2669666
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

The human genome has widespread three-dimensional organization. New Hi-C methods first identified TADs, which are regions of chromosomes characterized by a high frequency of self-interaction. Many different aspects of this genetic domain have been studied in the past, such as the processes that lead to its formation, the regulatory roles it plays, the extent to which it has been conserved and stable across species throughout evolution, the diseases that are linked to TAD disruptions, and the identification methods that have recently been developed. With a literature review approach, this paper hopes to compile and synthesize previous findings concerning TAD regions, creating a reference extract for use in the future.

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Baoqin Fei "Investigations on topologically associated domains from functional, evolutionary, and technical perspectives", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126113J (24 March 2023); https://doi.org/10.1117/12.2669666

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