Ultra-miniaturised spatial frequency domain imaging for improved early detection of gastrointestinal cancers

Jane Crowley; George S. D. Gordon

doi:10.1117/12.2648766

16 March 2023 Ultra-miniaturised spatial frequency domain imaging for improved early detection of gastrointestinal cancers

Jane Crowley, George S. D. Gordon

Author Affiliations +

Proceedings Volume 12393, Biomedical Applications of Light Scattering XIII; 1239302 (2023) https://doi.org/10.1117/12.2648766
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The low five year-survival rates for gastrointestinal cancers evidences a strong clinical need to improve their early detection. Current imaging methods for early detection are expensive and rely on white light imaging which lacks sufficient contrast to spot a wide range of potential tumours. Changes in absorption and reduced scattering coefficients can be linked to pre-cancerous abnormalities, such as Barrett’s Oesophagus, and invasive squamous cell carcinoma, in the oesophagus. Spatial Frequency Domain Imaging (SFDI) is a low-cost imaging technique from which quantitative maps of absorption and reduced scattering coefficients may be obtained using structured illumination. We have developed a clinically translatable, ultra-miniaturised SFDI system using optical fibers (0.125 mm diameter) to project structured illumination and a miniature camera (< 1 mm diameter) to capture the pattern response for a sample under test. The total package could therefore be made < 1.1mm diameter, representing, to the best of our knowledge, the smallest full SFDI probe achieved to date. We have demonstrated recovery of absorption and reduced scattering maps with our system for tissue mimicking co-polymer in oil phantoms of biologically relevant absorption and scattering properties. This technology represents a first step towards a less-invasive, cost-effective device which produces close to real-time absorption and reduced scattering maps for improved in vivo disease detection of the gastrointestinal tract.

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Jane Crowley and George S. D. Gordon "Ultra-miniaturised spatial frequency domain imaging for improved early detection of gastrointestinal cancers", Proc. SPIE 12393, Biomedical Applications of Light Scattering XIII, 1239302 (16 March 2023); https://doi.org/10.1117/12.2648766

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KEYWORDS

Optical properties

Absorption

Biological imaging

Cancer

Light sources and illumination

Scattering

Cameras

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