Fast fluorescent wavefront-shaping using incoherent iterative time reversal (Conference Presentation)

Anat Levin

doi:10.1117/12.2654829

16 March 2023 Fast fluorescent wavefront-shaping using incoherent iterative time reversal (Conference Presentation)

Anat Levin

Proceedings Volume 12388, Adaptive Optics and Wavefront Control for Biological Systems IX; 1238807 (2023) https://doi.org/10.1117/12.2654829
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We present a rapid approach for the estimation of a wavefront shaping modulation from single-photon (linear) fluorescent sources. The approach uses non-invasive, guide star free feedback. While estimating a wavefront shaping correction from real tissue samples is a complex time-consuming task, iterative time reversal techniques, previously designed for coherent illumination, carry the potential to reduce this acquisition cost. For that, they assume the desired correction mask is an eigenvector of the tissue transmission operator, and compute it using a small number of power iterations. Unfortunately, under coherent illumination, this approach can only handle restricted targets. We extend this idea to incoherent fluorescent targets. We show that the incoherent summation allows the approach to handle a larger family of targets and also accelerates its convergence.

Conference Presentation

Citation Download Citation

Anat Levin "Fast fluorescent wavefront-shaping using incoherent iterative time reversal (Conference Presentation)", Proc. SPIE 12388, Adaptive Optics and Wavefront Control for Biological Systems IX, 1238807 (16 March 2023); https://doi.org/10.1117/12.2654829

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KEYWORDS

Biomedical optics

Statistical modeling

Scattering

Speckle

Monte Carlo methods

Tissues

Computer simulations

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