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FCCS (fluorescence cross correlation spectroscopy) is a powerful tool to characterize drug target interaction in physiological environments. Over the last decade this technology was used to understand the binding and kinetics of small molecules and antibodies to challenging target proteins in great details and accuracy. Over the last decade Intana Bioscience expanded the application of FCCS from affinity measurements to comprehensive interaction studies including kinetics, multi component complex formation, assessing stoichiometry and quantification of aggregation, PK studies and target engagement. This presentation will highlight examples of results obtained with FCCS in projects ranging from early stages in the drug discovery up to the support of clinical trials to quantify target occupancies in patient samples.
Frank Becker
"Use of FCCS in drug discovery and development and presentation of a novel dedicated instrument for industrial FCCS applications", Proc. SPIE 12386, Single Molecule Spectroscopy and Superresolution Imaging XVI, 1238607 (15 March 2023); https://doi.org/10.1117/12.2650018
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Frank Becker, "Use of FCCS in drug discovery and development and presentation of a novel dedicated instrument for industrial FCCS applications," Proc. SPIE 12386, Single Molecule Spectroscopy and Superresolution Imaging XVI, 1238607 (15 March 2023); https://doi.org/10.1117/12.2650018