Iodine quantification in dual-energy mammography: linearity, bias and variability

G. Pacheco-Guevara; J. P. Castillo-Lopez; Y. Villaseñor-Navarro; M. E. Brandan

doi:10.1117/12.2625782

13 July 2022 Iodine quantification in dual-energy mammography: linearity, bias and variability

G. Pacheco-Guevara, J. P. Castillo-Lopez, Y. Villaseñor-Navarro, M. E. Brandan

Proceedings Volume 12286, 16th International Workshop on Breast Imaging (IWBI2022); 1228609 (2022) https://doi.org/10.1117/12.2625782
Event: Sixteenth International Workshop on Breast Imaging, 2022, Leuven, Belgium

Abstract

Contrast-enhanced digital mammography (CEDM) is used to detect iodine uptake in breast lesions. Iodine concentrations inside or around breast lesions could be used as a biomarker, provided a properly characterized quantification method is implemented. In this work, we have evaluated a method to quantify iodine concentrations in CEDM in terms of its intrinsic linearity, bias and variability. This evaluation was performed in a virtual clinical trial (VCT) environment, simulating anthropomorphic breast phantoms containing solid and liquid lesions with different iodine concentrations. Our results showed that anatomical variables such as breast size and lesion size and composition have a considerable effect on the iodine quantification. The method was linear in the clinical iodine concentration range, and showed an approximately constant 1 mg/cm² bias in the 0 – 2 mg/cm² range for both solid and liquid lesions. Corrections were proposed that reduced the variability due to breast size, lesion size, and composition.

Citation Download Citation

G. Pacheco-Guevara, J. P. Castillo-Lopez, Y. Villaseñor-Navarro, and M. E. Brandan "Iodine quantification in dual-energy mammography: linearity, bias and variability", Proc. SPIE 12286, 16th International Workshop on Breast Imaging (IWBI2022), 1228609 (13 July 2022); https://doi.org/10.1117/12.2625782

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