With the development of astronomy, more requirements of low noise and high frame rate are put forward for observation instruments. With the advancement of CMOS technology, scientific CMOS camera can provide excellent quantum efficiency, noise performance, and higher frame rate compared to CCD camera. Based on this, we have designed a scientific CMOS camera with 2K*2K pixels and 11um pixel size. The frame rate of the camera could reach 48fps, with very low readout noise. The structural design, electronic design, cooling method and data processing of the camera will be introduced in this paper.
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