The application of nanomaterials for targeted antimicrobial delivery

Yidan Lyu

doi:10.1117/12.2637182

10 June 2022 The application of nanomaterials for targeted antimicrobial delivery

Yidan Lyu

Proceedings Volume 12179, Second International Conference on Medical Imaging and Additive Manufacturing (ICMIAM 2022); 121790O (2022) https://doi.org/10.1117/12.2637182
Event: Second International Conference on Medical Imaging and Additive Manufacturing (ICMIAM 2022), 2022, Xiamen, China

Abstract

Currently, the emergence of resistant pathogenic strains of conventional antibiotics poses an obstacle to disease treatment and an increasingly serious threat to human health. Antimicrobial peptides (AMPs) are considered to have promising applications in the pharmaceutical industry due to their advantages such as high antimicrobial activity, broad antimicrobial spectrum and the unlikelihood of resistance mutations in the target strains. Antimicrobial peptides, also known as host defense peptides (HDPs), are naturally occurring biomolecules. Certain antimicrobial peptides have great potential in the fight against microbial infections due to their ability to directly kill or inhibit bacterial activity and also potentially have the capacity to modulate the host's immune response. However, many limitations to the efficacy of antimicrobial peptides, including rapid degradation, systemic toxicity, and low bioavailability, make the search for improved approaches an urgent one. Advances in nanomedicine have provided ideas for the optimization of delivery systems for antimicrobial peptides, and research on a variety of targeted delivery systems using nanomaterials as carriers has made progress in the fight against microbial infections. This nanomaterial-based delivery method combines the good biocompatibility of delivery carriers with the unhindered activity of free AMP, which contributes greatly to the advancement of AMP therapy for clinical applications.

Citation Download Citation

Yidan Lyu "The application of nanomaterials for targeted antimicrobial delivery", Proc. SPIE 12179, Second International Conference on Medical Imaging and Additive Manufacturing (ICMIAM 2022), 121790O (10 June 2022); https://doi.org/10.1117/12.2637182

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