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Human brain cells are being traumatized using a dielectric elastomer actuator (DEA) cell injury device (CID). The DEAs on the CID share the same membrane as plated human pericytes, delivering an abrupt 20% strain to the cell culture thus producing an insult similar to traumatic brain injury (TBI). In this first phase of the study, we have subjected the pericytes to 50 stretching cycles at 1 Hz. 24 hours after injury, a quantitative real-time polymerase chain reaction has shown a twofold gene change for c-jun, a known inflammation marker. The CID provides a platform for the advancement of TBI pharmacology.
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Samuel Rosset, Yi-Han Wu, Sahan Jayatissa, Thomas Park, Michael Dragunow, Iain A. Anderson, Vickie Shim, "Reproducing traumatic brain injury in vitro with dielectric elastomer actuators," Proc. SPIE 12042, Electroactive Polymer Actuators and Devices (EAPAD) XXIV, 1204203 (20 April 2022); https://doi.org/10.1117/12.2613823