Bacteriochlorophyll-a as photosensitizer for photodynamic treatment of transplantable murine tumors

Barbara W. Henderson; William R. Potter; Adam B. Sumlin; Barbara Owczarczak; F. S. Nowakowski; Thomas J. Dougherty

doi:10.1117/12.17667

1 July 1990 Bacteriochlorophyll-a as photosensitizer for photodynamic treatment of transplantable murine tumors

Barbara W. Henderson, William R. Potter, Adam B. Sumlin, Barbara Owczarczak, F. S. Nowakowski, Thomas J. Dougherty

Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17667
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

The photodynarnic effects of bacteriochlorophyll-a (bchl-a) , a sensitizer of high light absorption at long wavelengths, are greatly influenced by its rapid degradation in vivo to also photodynamically active pheophytins and chlorophylls. This can result in overall tumor destruction and direct tumor cell kill over a wide range of different wavelengths, although tumor curability is restricted to the bchl-a wavelength of 780 nm. Tumor cures are also limited to treatment conditions where light follows drug injection after a brief interval (2 hours) . The major mechanism of tumor destruction appears to be vascular. Normal tissue photosensitivity induced by 780 nm light declines rapidly with time after sensitizer injection.

Citation Download Citation

Barbara W. Henderson, William R. Potter, Adam B. Sumlin, Barbara Owczarczak, F. S. Nowakowski, and Thomas J. Dougherty "Bacteriochlorophyll-a as photosensitizer for photodynamic treatment of transplantable murine tumors", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); https://doi.org/10.1117/12.17667

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