Development of an NIR imaging technique in ex-vivo studies for needle-free jet injection systems

Abdul Mohizin; Jakir Hossain Imran; Jung Kyung Kim

doi:10.1117/12.2609152

3 March 2022 Development of an NIR imaging technique in ex-vivo studies for needle-free jet injection systems

Abdul Mohizin, Jakir Hossain Imran, Jung Kyung Kim

Proceedings Volume 11938, Visualizing and Quantifying Drug Distribution in Tissue VI; 1193808 (2022) https://doi.org/10.1117/12.2609152
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

A major challenge in the study of the physical mechanism behind needle-free jet injection (NFJI) systems is the lack of visualization techniques or tools to study the penetration and dispersion characteristics of the high-velocity microjet inside the skin tissue. Current imaging techniques used to assess skin permeation require a minimum temporal resolution of 1 ms, whereas a temporal resolution in the order of 100 μs is needed to study the penetration and dispersion phases of a NFJI system. In this study, we propose near-infrared (NIR) fluorescent and absorbance/transmission imaging techniques to achieve the temporal resolution required for visualization of NFJI studies. Fluorescent signals up to 2.5 mm could be obtained with a normal ex vivo porcine sample. However, absorbance/transmission imaging could not produce the required contrast in the normal ex vivo sample. Also, we apply a tissue clearing technique to improve the image acquisition for higher depth. In the cleared tissue sample, the lowest measured dimensional error was observed at a temporal resolution up to 50 and 10 μs for NIR fluorescent and absorbance/transmission imaging techniques, respectively.

Conference Presentation

Citation Download Citation

Abdul Mohizin, Jakir Hossain Imran, and Jung Kyung Kim "Development of an NIR imaging technique in ex-vivo studies for needle-free jet injection systems", Proc. SPIE 11938, Visualizing and Quantifying Drug Distribution in Tissue VI, 1193808 (3 March 2022); https://doi.org/10.1117/12.2609152

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