Red blood cell flow dynamics at bifurcations of the brain capillaries

Kazuto Masamoto; Ruka Sakuraba; Tomoya Niizawa

doi:10.1117/12.2615678

27 October 2021 Red blood cell flow dynamics at bifurcations of the brain capillaries

Kazuto Masamoto, Ruka Sakuraba, Tomoya Niizawa

Proceedings Volume 11925, Biomedical Imaging and Sensing Conference 2021; 119250U (2021) https://doi.org/10.1117/12.2615678
Event: SPIE Technologies and Applications of Structured Light, 2021, Online, Japan

Abstract

The purpose of the present study was to determine spatiotemporal dynamics of the red blood cell flow in the brain capillaries. To this end, two-photon microscopy was used to concurrently image blood plasma and blood cells expressing fluorescent proteins in the anesthetized rat cortex. Kymographic analysis showed that flow velocity of the red blood cells varied at the bifurcations of brain capillaries, indicating that the bifurcations serve as resistance for the red blood cell flow. Our results further suggest that interactions between the red blood cells and capillary lumen contribute to resistance to capillary flow.

Citation Download Citation

Kazuto Masamoto, Ruka Sakuraba, and Tomoya Niizawa "Red blood cell flow dynamics at bifurcations of the brain capillaries", Proc. SPIE 11925, Biomedical Imaging and Sensing Conference 2021, 119250U (27 October 2021); https://doi.org/10.1117/12.2615678

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