Quantitative evaluations on EUS-guided laser ablation in ex-vivo and in-vivo porcine pancreas

Van Gia Truong; Jin-Seok Park; Van Nam Tran; Hyun Wook Kang

doi:10.1117/12.2614455

7 December 2021 Quantitative evaluations on EUS-guided laser ablation in ex-vivo and in-vivo porcine pancreas

Van Gia Truong, Jin-Seok Park, Van Nam Tran, Hyun Wook Kang

Proceedings Volume 11919, Translational Biophotonics: Diagnostics and Therapeutics; 1191908 (2021) https://doi.org/10.1117/12.2614455
Event: European Conferences on Biomedical Optics, 2021, Online Only

Abstract

Endoscopic ultrasound (EUS)-guided laser ablation (LA) has been recently investigated for the treatment of pancreatic tumor. This study aimed to demonstrate the feasibility of EUS-guided LA in porcine pancreatic tissue to treat pancreatic tumor ablation with minimal thermal injury to adjacent tissue. A 1064-nm Nd:YAG laser was applied to both ex vivo and in vivo porcine pancreatic tissue through a diffusing applicator. Overall, coagulation diameter increased linearly with the applied power without carbonization and fiber degradation on ex vivo tests (i.e., R² = 0.87). Thediffusing applicator created a uniformly symmetrical laser ablation in pancreatic tissue. In vivo tests with EUS confirmed easy insertion and high durability of the diffusing applicator. The proposed EUS-guided diffusing LA can be a feasible therapeutic approach to effectively treat pancreatic tumor with predictable thermal ablation and enhanced safety

Citation Download Citation

Van Gia Truong, Jin-Seok Park, Van Nam Tran, and Hyun Wook Kang "Quantitative evaluations on EUS-guided laser ablation in ex-vivo and in-vivo porcine pancreas", Proc. SPIE 11919, Translational Biophotonics: Diagnostics and Therapeutics, 1191908 (7 December 2021); https://doi.org/10.1117/12.2614455

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