Primarily study of non-thermal tumor ablation method based on terahertz free electron laser

Jun Zhou; Zhenzhen Ge; Peidu Jiang; Xin Rao; Shuting Wu; Jiajia Qian; Dai Wu; Peng Li; Peng Zhang; Longgang Yan; Ming Li

doi:10.1117/12.2605702

9 September 2021 Primarily study of non-thermal tumor ablation method based on terahertz free electron laser

Jun Zhou, Zhenzhen Ge, Peidu Jiang, Xin Rao, Shuting Wu, Jiajia Qian, Dai Wu, Peng Li, Peng Zhang, Longgang Yan, Ming Li

Author Affiliations +

Proceedings Volume 11909, Tenth International Symposium on Ultrafast Phenomena and Terahertz Waves (ISUPTW 2021); 119090Z (2021) https://doi.org/10.1117/12.2605702
Event: Tenth International Symposium on Ultrafast Phenomena and Terahertz Waves (ISUPTW 2021), 2021, Chengdu, China

Abstract

Non-thermal tumor ablation technology based on short pulse strong electric field can overcome the defects of thermal ablation and cryoablation, which provides a new opportunity for the development of tumor therapy. In this study, the CAEP terahertz free electron laser facility was preliminarily used to do the research on non-thermal tumor ablation method because of its unique macro-micro pulse time series. The biological effects of short pulse strong field terahertz radiation on melanoma cells and tissues were studied in vitro and in vivo. In vitro experiments show that the survival rate of tumor cells is significantly different after being irradiated by different frequency, power, and radiation duration of terahertz wave. Strong field terahertz wave can inhibit the proliferation of tumor cells. In vivo experiments showed that compared with the control group, the tumor tissue proliferation of the irradiated experimental group was slowed down, the tumor volume was gradually reduced, and the strong field terahertz pulses could inhibit the growth of tumor tissue. These preliminary results will provide a feasible reference for further research and long-term clinical application.

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Jun Zhou, Zhenzhen Ge, Peidu Jiang, Xin Rao, Shuting Wu, Jiajia Qian, Dai Wu, Peng Li, Peng Zhang, Longgang Yan, and Ming Li "Primarily study of non-thermal tumor ablation method based on terahertz free electron laser", Proc. SPIE 11909, Tenth International Symposium on Ultrafast Phenomena and Terahertz Waves (ISUPTW 2021), 119090Z (9 September 2021); https://doi.org/10.1117/12.2605702

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