Laboratory x-ray fluorescence computed tomography for in vivo preclinical imaging

Kian Shaker; Giovanni Marco Saladino; Carmen Vogt; Yurika Katsu-Jimenéz; Bertha Brodin; Raoul V. Kuiper; Kenth Andersson; Yuyang Li; Jakob C. Larsson; Martin Svenda; Aida Rodriguez-Garcia; Muhammet S. Toprak; Marie Arsenian-Henriksson; Hans M. Hertz

doi:10.1117/12.2595614

1 August 2021 Laboratory x-ray fluorescence computed tomography for in vivo preclinical imaging

Kian Shaker, Giovanni Marco Saladino, Carmen Vogt, Yurika Katsu-Jimenéz, Bertha Brodin, Raoul V. Kuiper, Kenth Andersson, Yuyang Li, Jakob C. Larsson, Martin Svenda, Aida Rodriguez-Garcia, Muhammet S. Toprak, Marie Arsenian-Henriksson, Hans M. Hertz

Author Affiliations +

Proceedings Volume 11840, Developments in X-Ray Tomography XIII; 118400Y (2021) https://doi.org/10.1117/12.2595614
Event: SPIE Optical Engineering + Applications, 2021, San Diego, California, United States

Abstract

Laboratory x-ray fluorescence (XRF) computed tomography (XFCT) with nanoparticles (NPs) as contrast agents now allows for in vivo preclinical imaging and longitudinal studies at low radiation dose. We present on developments of our XFCT arrangement capable of low-dose (<25 mGy) imaging with high signal-to-background resulting in high-spatial-resolution (200-400 μm) in vivo imaging of Ru, Rh and Mo NPs injected and accumulated locally in mice. We further demonstrate multiplexing capabilities by cross-talk-free separation of Ru, Rh and Mo XRF signal as well as envisioning the future of preclinical XFCT for active targeting and imaging of molecular markers (e.g., cancer cells).

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Kian Shaker, Giovanni Marco Saladino, Carmen Vogt, Yurika Katsu-Jimenéz, Bertha Brodin, Raoul V. Kuiper, Kenth Andersson, Yuyang Li, Jakob C. Larsson, Martin Svenda, Aida Rodriguez-Garcia, Muhammet S. Toprak, Marie Arsenian-Henriksson, and Hans M. Hertz "Laboratory x-ray fluorescence computed tomography for in vivo preclinical imaging", Proc. SPIE 11840, Developments in X-Ray Tomography XIII, 118400Y (1 August 2021); https://doi.org/10.1117/12.2595614

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