Mid-infrared photothermal quantitative phase imaging

Takuro Ideguchi

doi:10.1117/12.2578168

5 March 2021 Mid-infrared photothermal quantitative phase imaging

Takuro Ideguchi

Proceedings Volume 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021; 116561K (2021) https://doi.org/10.1117/12.2578168
Event: SPIE BiOS, 2021, Online Only

Abstract

We develop a chemically-selective quantitative phase imaging technique based on mid-infrared photothermal effect, with which we can simultaneously measure a morphologically sensitive quantitative phase image and a molecularly sensitive mid-infrared photothermal phase image. We show that the wide-field label-free dual-modal microscopy technique can be implemented with digital holography (2D) and optical diffraction tomography (3D). We also demonstrate a new technique to improve the sensitivity of the mid-infrared photothermal phase imaging via a dynamic-range expanded quantitative phase imaging, called adaptive dynamic range shift quantitative phase imaging (ADRIFT-QPI).

Conference Presentation

Citation Download Citation

Takuro Ideguchi "Mid-infrared photothermal quantitative phase imaging", Proc. SPIE 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021, 116561K (5 March 2021); https://doi.org/10.1117/12.2578168

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