Quantifying human cutaneous pharmacokinetics

Conor L. Evans

doi:10.1117/12.2577713

5 March 2021 Quantifying human cutaneous pharmacokinetics

Conor L. Evans

Proceedings Volume 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021; 1165608 (2021) https://doi.org/10.1117/12.2577713
Event: SPIE BiOS, 2021, Online Only

Abstract

Coherent Raman scattering (CRS) imaging is capable of directly imaging the diffusion and uptake of drugs into tissue, enabling the direct quantification of pharmacokinetics and the extraction of key pharmacokinetic parameters such as Tmax. We will present our work translating this toolkit to the study of percutaneous pharmacokinetics in human skin and clinical studies. Our ongoing work incorporates new machine learning models to map drug PK to human skin morphorology, as well as portable coherent Raman imaging tools for pharmacokinetic studies directly in diseased skin.

Conference Presentation

Citation Download Citation

Conor L. Evans "Quantifying human cutaneous pharmacokinetics", Proc. SPIE 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021, 1165608 (5 March 2021); https://doi.org/10.1117/12.2577713

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