Visualizing the full depth of the human uterine wall through three-dimensional mosaic Optical Coherence Tomography

Isaac C. Donis; James P. McLean; Christine P. Hendon

doi:10.1117/12.2577426

5 March 2021 Visualizing the full depth of the human uterine wall through three-dimensional mosaic Optical Coherence Tomography

Isaac C. Donis, James P. McLean, Christine P. Hendon

Author Affiliations +

Proceedings Volume 11649, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVIII; 1164913 (2021) https://doi.org/10.1117/12.2577426
Event: SPIE BiOS, 2021, Online Only

Abstract

We propose a method to construct a three-dimensional volumetric representation of uterine tissue through the full thickness of the uterine wall using Optical Coherence Tomography (OCT). Uterine tissue blocks from human donors were cut into ~4 mm thin slices and imaged on both sides using a commercial OCT system with 2 mm imaging depth. Attenuation compensation, rigid registration, image blending techniques were used to combine the OCT mosaic volumes from each side of the tissue into a single volume. Initial results suggest this method yields a representative 3D view of uterine collagen fiber architecture through the full tissue thickness.

Conference Presentation

Citation Download Citation

Isaac C. Donis, James P. McLean, and Christine P. Hendon "Visualizing the full depth of the human uterine wall through three-dimensional mosaic Optical Coherence Tomography", Proc. SPIE 11649, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVIII, 1164913 (5 March 2021); https://doi.org/10.1117/12.2577426

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