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5 March 2021 Age-related changes in collagen mechanical properties detected by high-resolution acoustic microscopy and AFM
Anna R. Maeva, Adam P. Strange, Inna Seviaryna, Colin Hopper, Conal Perrett, Hugh Trahair, Oliver Devine, Arne Akbar
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Proceedings Volume 11645, Optical Elastography and Tissue Biomechanics VIII; 116450V (2021) https://doi.org/10.1117/12.2585637
Event: SPIE BiOS, 2021, Online Only
Abstract
Skin aging is a complex process accompanied by alterations in skin structure and function. We have investigated the age-related changes in collagen on dermal collagen’s physical properties. Nanomechanical properties of collagen fibrils studied using atomic force microscope nano-indentation and viscoelasticity of the collagen fibers assessed by the acoustic microscopy was investigated. The increase in Young’s modulus with increased age correlated with the increase in sound speed and attenuation is probably due to a change in the density of the fibrils caused by water retention within the fibrils and cross-linkage between fibrils.
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Anna R. Maeva, Adam P. Strange, Inna Seviaryna, Colin Hopper, Conal Perrett, Hugh Trahair, Oliver Devine, and Arne Akbar "Age-related changes in collagen mechanical properties detected by high-resolution acoustic microscopy and AFM", Proc. SPIE 11645, Optical Elastography and Tissue Biomechanics VIII, 116450V (5 March 2021); https://doi.org/10.1117/12.2585637
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KEYWORDS
Collagen
Microscopy
Acoustics
Skin
Atomic force microscopy
Atomic force microscope
Diagnostics
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