Towards non-contact functional oxygen metabolism estimation with multi-wavelength photoacoustic remote sensing and Doppler optical coherence tomography

Matthew T. Martell; Nathaniel J. M. Haven; Pradyumna Kedarisetti; Roger J. Zemp; Brendon Restall

doi:10.1117/12.2578942

5 March 2021 Towards non-contact functional oxygen metabolism estimation with multi-wavelength photoacoustic remote sensing and Doppler optical coherence tomography

Matthew T. Martell, Nathaniel J. M. Haven, Pradyumna Kedarisetti, Roger J. Zemp, Brendon Restall

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Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 1164233 (2021) https://doi.org/10.1117/12.2578942
Event: SPIE BiOS, 2021, Online Only

Abstract

Photoacoustic remote sensing (PARS) microscopy with multi-wavelength excitation and spectral unmixing was recently reported for non-contact imaging of hemoglobin oxygen saturation. In this work, we aim to extend this technique to provide additional functional information on oxygen metabolic activity. Stimulated Raman scattering provides multi-wavelength PARS excitation for SO2 estimation, and is integrated with Doppler OCT for quantitative blood flow rate determination. Structural imaging is demonstrated in phantoms and in vivo angiography. To evaluate system performance, tube phantoms containing blood of varied oxygenation and flow rates were imaged. This represents progress towards deploying the technique for in vivo oxygen consumption monitoring.

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Matthew T. Martell, Nathaniel J. M. Haven, Pradyumna Kedarisetti, Roger J. Zemp, and Brendon Restall "Towards non-contact functional oxygen metabolism estimation with multi-wavelength photoacoustic remote sensing and Doppler optical coherence tomography", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 1164233 (5 March 2021); https://doi.org/10.1117/12.2578942

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KEYWORDS

Optical coherence tomography

Oxygen

Doppler tomography

Photoacoustic spectroscopy

Remote sensing

Mode conditioning cables

Image resolution

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