Broadband fiber optic photoacoustic probe for functional brain imaging

Yizhi Liang; Xiaoxuan Zhong; Long Jin; Lidai Wang; Huan Liu

doi:10.1117/12.2577419

5 March 2021 Broadband fiber optic photoacoustic probe for functional brain imaging

Yizhi Liang, Xiaoxuan Zhong, Long Jin, Lidai Wang, Huan Liu

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116422V (2021) https://doi.org/10.1117/12.2577419
Event: SPIE BiOS, 2021, Online Only

Abstract

Here we report a high performance fiber-based photoacoustic microscope for brain sO₂ imaging. The critical element is a fiber-optic ultrasound sensor, which translates the megahertz acoustic waves into detectable lasing frequency variations. Its working bandwidth has been extended to 40 MHz, by reducing the fiber diameter to 58 μm via chemical etching, this sensor should good result in brain sO₂ imaging. The fiber-based PAM offers a new strategy to implement a head-mounted microscope to continuously monitor the brain activities of an awake, free-moving small animal.

Conference Presentation

Citation Download Citation

Yizhi Liang, Xiaoxuan Zhong, Long Jin, Lidai Wang, and Huan Liu "Broadband fiber optic photoacoustic probe for functional brain imaging", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116422V (5 March 2021); https://doi.org/10.1117/12.2577419

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