Androniki Mitrou,1 Xin Feng,1 Ashraf Khan,2,3 Anna Yaroslavsky1
1Advanced Biophotonics Lab., Univ. of Massachusetts Lowell (United States) 2Univ. of Massachusetts Medical School (United States) 3Baystate Health (United States)
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
This study investigated the combination of two contrast agents for ex vivo cancer detection in breast tissues. Samples were stained with molecular marker pH Low Insertion Peptide (pHLIP) conjugated with fluorescent dye Alexa532 (pHLIP–Alexa532), and intravital stain Methylene Blue (MB), and imaged with a high-resolution confocal microscope. Resulting images display cellular morphology with staining patterns mimicking Hematoxylin and Eosin histopathology and show promise for the method used as a tool for breast cancer detection in biopsies or intraoperatively.
Androniki Mitrou,Xin Feng,Ashraf Khan, andAnna Yaroslavsky
"Dual-contrast high resolution imaging of breast cancer", Proc. SPIE 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1163604 (5 March 2021); https://doi.org/10.1117/12.2577323
ACCESS THE FULL ARTICLE
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Androniki Mitrou, Xin Feng, Ashraf Khan, Anna Yaroslavsky, "Dual-contrast high resolution imaging of breast cancer," Proc. SPIE 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1163604 (5 March 2021); https://doi.org/10.1117/12.2577323