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5 March 2021 In vivo evaluation of inner and outer retinal water transport associated with light activation of photoreceptors after dark adaptation in mice
Robert J. Zawadzki, Pengfei Zhang, Sarah J. Karlen, Edward N. Pugh Jr.
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Proceedings Volume 11623, Ophthalmic Technologies XXXI; 1162314 (2021) https://doi.org/10.1117/12.2583262
Event: SPIE BiOS, 2021, Online Only
Abstract
The development of functional retinal imaging is of great interest to clinical and experimental ophthalmology. Recent progress in OCT-based functional imaging of rods and/or cones outer segments elongations in response to stimuli that bleach fraction of their rhodopsin promises to address the need for probing photoreceptor function. Building on this model, we developed the framework to monitor changes in the gross morphology of the whole retina of mice in response to light stimulation. In our current submission, we will discuss our findings in the context of known retinal water barriers restricting water movements between inner and outer retina.
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Robert J. Zawadzki, Pengfei Zhang, Sarah J. Karlen, and Edward N. Pugh Jr. "In vivo evaluation of inner and outer retinal water transport associated with light activation of photoreceptors after dark adaptation in mice", Proc. SPIE 11623, Ophthalmic Technologies XXXI, 1162314 (5 March 2021); https://doi.org/10.1117/12.2583262
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KEYWORDS
In vivo imaging
Image segmentation
Retina
Retinal scanning
Cones
Diagnostics
Functional imaging
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