Adaptive optics (AO) enables retinal imaging at cellular resolution. Today, most ophthalmic AO systems have closed-loop bandwidths of ≤2 Hz, insufficient for many conditions encountered in the clinic. Here, we develop an ultrafast AO with a bandwidth of 32.6 Hz and evaluate its use with optical coherence tomography. After AO activation, the RMS wavefront aberration from an un-cyclopleged human eye dropped below diffraction limit within 5 ms, 40× faster than the fastest ophthalmic AO system reported in the literature. Because the system converges so quickly, we can use the data immediately after a blink or when imaging locations are changed, even in eyes wearing contact lenses.
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