Microbubble-assisted concentration and ultrasensitive detection of chiral biomolecules using plasmonic chiral metamaterials

Yaoran Liu; Zilong Wu; Yuebing Zheng

doi:10.1117/12.2568024

19 August 2020 Microbubble-assisted concentration and ultrasensitive detection of chiral biomolecules using plasmonic chiral metamaterials

Yaoran Liu, Zilong Wu, Yuebing Zheng

Author Affiliations +

Proceedings Volume 11462, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XVIII; 1146229 (2020) https://doi.org/10.1117/12.2568024
Event: SPIE Nanoscience + Engineering, 2020, Online Only

Conference Poster

Abstract

We have developed microbubble-assisted rapid concentration and ultrahigh-sensitive detection of multiple chiral metabolites. Through the strong Marangoni convection, the drag force can efficiently drag and print the biomolecules with hundreds of molar masses on the plasmonic substrates for chiral analysis, breaking the limit of conventional electrophoresis and thermophoresis in the manipulation of molecules. We show that we can detect and differentiate 100 pM D/L pure glucose solution, which shows 107 times greater sensitivity than the state-of-the-art chiral sensing techniques. Finally, we successfully detect the enantiomer excess in purified urine and therefore push the label-free lab-on-a-chip detection of chiral biomarkers for diabetes mellitus detection.

Citation Download Citation

Yaoran Liu, Zilong Wu, and Yuebing Zheng "Microbubble-assisted concentration and ultrasensitive detection of chiral biomolecules using plasmonic chiral metamaterials", Proc. SPIE 11462, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XVIII, 1146229 (19 August 2020); https://doi.org/10.1117/12.2568024

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available