Functional metasurfaces for rapid, colorimetric cancer tissue diagnostics (Conference Presentation)

Lisa V. Poulikakos; Mark Lawrence; David R. Barton III; Jennifer A. Dionne

doi:10.1117/12.2551314

10 March 2020 Functional metasurfaces for rapid, colorimetric cancer tissue diagnostics (Conference Presentation)

Lisa V. Poulikakos, Mark Lawrence, David R. Barton III, Jennifer A. Dionne

Author Affiliations +

Proceedings Volume 11257, Plasmonics in Biology and Medicine XVII; 112570I (2020) https://doi.org/10.1117/12.2551314
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We present an all-optical, label-free technology for quantitative, real-time cancer tissue diagnostics on a single, clinically-compatible chip. Periodically-arranged sub-wavelength dielectric nanostructures, known as metasurfaces, are patterned into dielectric layers on glass microscope coverslips, where biopsied tumor tissue sections can be deposited following routine clinical procedure. We numerically and experimentally map the anisotropy and orientation of collagen fibers, a quantitative marker of cancer stage in tissue, onto metasurface structural color. Working at the interface of nanoscale optics and medicine, our colorimetric metasurface platform has the potential to set a new benchmark for rapid, quantitative and cost-effective cancer tissue diagnostics.

Conference Presentation

Citation Download Citation

Lisa V. Poulikakos, Mark Lawrence, David R. Barton III, and Jennifer A. Dionne "Functional metasurfaces for rapid, colorimetric cancer tissue diagnostics (Conference Presentation)", Proc. SPIE 11257, Plasmonics in Biology and Medicine XVII, 112570I (10 March 2020); https://doi.org/10.1117/12.2551314

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