A luminescent oxygen-sensing hydrogel for mapping tissue oxygenation (Conference Presentation)

Haley L. Marks; Juan Pedro Cascales Sandoval; Joshua Glahn; Katherine Cook; Emmanuel Roussakis; Mark W. Grinstaff; Dieter Manstein; Conor L. Evans

doi:10.1117/12.2544561

10 March 2020 A luminescent oxygen-sensing hydrogel for mapping tissue oxygenation (Conference Presentation)

Haley L. Marks, Juan Pedro Cascales Sandoval, Joshua Glahn, Katherine Cook, Emmanuel Roussakis, Mark W. Grinstaff, Dieter Manstein, Conor L. Evans

Author Affiliations +

Proceedings Volume 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII; 112560F (2020) https://doi.org/10.1117/12.2544561
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

There is an unmet need for simple-to-use oximetry devices that can map tissue oxygenation over large areas while being easily integrated into clinical standard-of-care workflows. We present a phosphorescence-based approach which features red-emitting porphyrin molecule constructs, embedded within a paint-on hydrogel bandage for tissue oxygen concentration imaging. The bandage emission is visible by eye which enables oxygen imaging even in the presence of skin autofluorescence. Preclinical testing to validate correlations between bandage oxygenation maps and perfusion is ongoing, and by allowing gelation to occur on the skin the bandage can conform to odd topologies, such as ears.

Conference Presentation

Citation Download Citation

Haley L. Marks, Juan Pedro Cascales Sandoval, Joshua Glahn, Katherine Cook, Emmanuel Roussakis, Mark W. Grinstaff, Dieter Manstein, and Conor L. Evans "A luminescent oxygen-sensing hydrogel for mapping tissue oxygenation (Conference Presentation)", Proc. SPIE 11256, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XII, 112560F (10 March 2020); https://doi.org/10.1117/12.2544561

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