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9 March 2020 Eliminating drug-resistant bacteria and fungal infections via one-photon and multi-photon bleaching of intrinsic chromophores (Conference Presentation)
Ji-Xin Cheng
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Proceedings Volume 11244, Multiphoton Microscopy in the Biomedical Sciences XX; 112440K (2020) https://doi.org/10.1117/12.2543378
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Antibiotic resistance kills an estimated 700,000 people each year worldwide, and study predicts that this number could rise to 10 million by 2050 if efforts are not made to curtail resistance (Nature, 2017, 543:15). Yet, the pace of resistance acquisition from mutation in pathogens is faster than clinical introduction of new antibiotics. This severe situation calls for an urgent need of developing unconventional ways to combat the resistance. To tackle this challenge, we are developing a novel phototherapy platform for fighting against a broad spectrum of drug-resistant infections. In particular, we have found that many intrinsic chromophores are probe to photobleaching through one-photon and even two-photon absorption. Importantly, these chromophores are virulence factors or essential for bacteria to survive in a stressed condition. Thus, photo-destruction of these intrinsic chromophores sensitizes the bacteria to attack by ROS or conventional antibiotics. Unlike photodynamic therapy,
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Ji-Xin Cheng "Eliminating drug-resistant bacteria and fungal infections via one-photon and multi-photon bleaching of intrinsic chromophores (Conference Presentation)", Proc. SPIE 11244, Multiphoton Microscopy in the Biomedical Sciences XX, 112440K (9 March 2020); https://doi.org/10.1117/12.2543378
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KEYWORDS
Chromophores
Bacteria
Resistance
Absorption
Pathogens
Photodynamic therapy
Phototherapy
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