Functional optical-resolution photoacoustic microscopy with ultra-short pulse delay (Conference Presentation)

Yingying Zhou; Siyi Liang; Lidai Wang; Puxiang Lai

doi:10.1117/12.2545481

6 March 2020 Functional optical-resolution photoacoustic microscopy with ultra-short pulse delay (Conference Presentation)

Yingying Zhou, Siyi Liang, Lidai Wang, Puxiang Lai

Author Affiliations +

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 1124025 (2020) https://doi.org/10.1117/12.2545481
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Fast switch between pulses of sufficient energy but different wavelengths plays an important role in fast functional photoacoustic imaging. Commonly used Stimulated Raman scattering through a long optical fiber can produce multiple wavelengths, but longer fiber means lower energy, which would decrease image quality. Shorter optical fiber is thus more desired for fast imaging. However, it should be noted that too short pulse separation may generate photoacoustic signals that are temporally overlapped. Here, we propose an approach to solve this overlapping problem in ultrafast PA imaging using a Fourier-domain based method. The validity of this method is confirmed through simulation firstly, and then it is applied to separate overlapped PA signals. Lastly, in vivo OR-PAM mapping of mouse ear’s sO2 photoacoustic imaging is achieved.

Conference Presentation

Citation Download Citation

Yingying Zhou, Siyi Liang, Lidai Wang, and Puxiang Lai "Functional optical-resolution photoacoustic microscopy with ultra-short pulse delay (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 1124025 (6 March 2020); https://doi.org/10.1117/12.2545481

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KEYWORDS

Photoacoustic microscopy

Optical fibers

Photoacoustic imaging

Ultrafast imaging

Fast packet switching

In vivo imaging

Photoacoustic spectroscopy

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