High-speed wide-field multi-parametric photoacoustic microscopy (Conference Presentation)

Fenghe Zhong; Ruimin Chen; Qifa Zhou; Song Hu

doi:10.1117/12.2545036

6 March 2020 High-speed wide-field multi-parametric photoacoustic microscopy (Conference Presentation)

Fenghe Zhong, Ruimin Chen, Qifa Zhou, Song Hu

Proceedings Volume 11240, Photons Plus Ultrasound: Imaging and Sensing 2020; 112401Y (2020) https://doi.org/10.1117/12.2545036
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We report a new multi-parametric photoacoustic microscopy (PAM) system, which enables high-resolution imaging of blood perfusion, oxygenation and flow at 0.2-Hz frame rate over an area of 4.5×4.5 mm2. Extending the laser scanning range by using a cylindrically focused transducer (focus: 50 µm by 4.5 mm), it increases the speed of our previous hybrid-scan system with a weakly focused transducer (focal diameter: 250 µm) by 18-fold without compromising the sensitivity. We have demonstrated the feasibility of this technique in the transmission mode in vivo. Further development of a reflection-mode system will enable real-time cortex-wide imaging of cerebral hemodynamics and metabolism.

Conference Presentation

Citation Download Citation

Fenghe Zhong, Ruimin Chen, Qifa Zhou, and Song Hu "High-speed wide-field multi-parametric photoacoustic microscopy (Conference Presentation)", Proc. SPIE 11240, Photons Plus Ultrasound: Imaging and Sensing 2020, 112401Y (6 March 2020); https://doi.org/10.1117/12.2545036

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