Large field of view macroscopic Raman line-scanning imaging system for neuro-oncology applications (Conference Presentation)

Francois Daoust; Patrick Orsini; Jacques Bismuth; Marie-Maude de Denus-Baillargeon; Israel Veilleux; Alexandre Wetter; Philippe McKoy; Isabelle Dicaire; Maroun Massabki; Kevin Petrecca; Frédéric Leblond

doi:10.1117/12.2543047

9 March 2020 Large field of view macroscopic Raman line-scanning imaging system for neuro-oncology applications (Conference Presentation)

Francois Daoust, Patrick Orsini, Jacques Bismuth, Marie-Maude de Denus-Baillargeon, Israel Veilleux, Alexandre Wetter, Philippe McKoy, Isabelle Dicaire, Maroun Massabki, Kevin Petrecca, Frédéric Leblond

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Proceedings Volume 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry; 112360E (2020) https://doi.org/10.1117/12.2543047
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We present the development and preliminary results of a novel intraoperative line-scanning Raman imaging system, developed for neurosurgery applications. The system records fingerprint Raman spectral images over a large field of view of 1.0cm2 through a handheld imaging probe placed in gentle contact with the interrogated tissue. With a spatial resolution of 250µm2 and an acquisition time on the order of 10s, brain structure margins can be identified within an adequate timeframe for clinical applications. The system was designed using detailed optical simulations and its performance was verified on tissue phantoms and in vivo on animals using our laboratory’s Raman point system as reference.

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Francois Daoust, Patrick Orsini, Jacques Bismuth, Marie-Maude de Denus-Baillargeon, Israel Veilleux, Alexandre Wetter, Philippe McKoy, Isabelle Dicaire, Maroun Massabki, Kevin Petrecca, and Frédéric Leblond "Large field of view macroscopic Raman line-scanning imaging system for neuro-oncology applications (Conference Presentation)", Proc. SPIE 11236, Biomedical Vibrational Spectroscopy 2020: Advances in Research and Industry, 112360E (9 March 2020); https://doi.org/10.1117/12.2543047

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KEYWORDS

Imaging systems

Raman spectroscopy

Neuro-oncology

Spatial resolution

In vivo imaging

Real time imaging

Cameras

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