Multifractal OCT for optical detection of retinal function (Conference Presentation)

Subrata Batabyal; Sanghoon Kim; Michael Carlson; Weldon W. Wright; Samarendra K. Mohanty

doi:10.1117/12.2547004

9 March 2020 Multifractal OCT for optical detection of retinal function (Conference Presentation)

Subrata Batabyal, Sanghoon Kim, Michael Carlson, Weldon W. Wright, Samarendra K. Mohanty

Proceedings Volume 11227, Optogenetics and Optical Manipulation 2020; 112270J (2020) https://doi.org/10.1117/12.2547004
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Herein, we report use of near-infrared low-coherent light for non-contact, label-free in-vivo detection of retinal activity in response to visual illumination. Our multifractal phase-OCT employ phase/multifractal analysis to decipher layer specific cellular activity during visual stimulation to assess the functional state of retina. Our OCT-based interferometric technique coupled with in-depth multifractal analysis differentiated retinal activities between wild-type and mice with retinal dystrophy. Our findings open up possibility of clinical translation of multifractal phase-OCT for non-contact label free evaluation of retina health, progression of retinal dystrophies, and as well as for monitoring functional recovery after therapy.

Conference Presentation

Citation Download Citation

Subrata Batabyal, Sanghoon Kim, Michael Carlson, Weldon W. Wright, and Samarendra K. Mohanty "Multifractal OCT for optical detection of retinal function (Conference Presentation)", Proc. SPIE 11227, Optogenetics and Optical Manipulation 2020, 112270J (9 March 2020); https://doi.org/10.1117/12.2547004

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KEYWORDS

Visualization

Optical coherence tomography

Retina

In vivo imaging

Interferometry

Visual analytics

Diagnostics

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