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20 April 2020 In vivo quantitative molecular absorption of glycerol in human skin using coherent anti-Stokes Raman scattering (CARS) and two-photon auto-fluorescence (Conference Presentation)
Hervé Rigneault, Barbara Sarri, Xueqin Chen, Sébastien Grégoire, Jean-Baptiste Galey, Anne Potter, Thomas Bornschlögl
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Proceedings Volume 11219, Visualizing and Quantifying Drug Distribution in Tissue IV; 1121905 (2020) https://doi.org/10.1117/12.2542701
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
We introduce and validate a framework for imaging and quantifying active molecule penetration into human skin in vivo. Our approach combines nonlinear imaging microscopy modalities, such as two-photon excited auto-fluorescence (TPEF) and coherent anti-Stokes Raman scattering (CARS), together with the use of deuterated active molecules. The imaging framework is exemplified on topically applied glycerol diluted in various vehicles such as water and xanthan gel. In vivo glycerol quantitative percutaneous penetration over time is demonstrated, showing that, contrary to water, xanthan gel vehicle acts as a film reservoir that releases glycerol continuously over time.
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Hervé Rigneault, Barbara Sarri, Xueqin Chen, Sébastien Grégoire, Jean-Baptiste Galey, Anne Potter, and Thomas Bornschlögl "In vivo quantitative molecular absorption of glycerol in human skin using coherent anti-Stokes Raman scattering (CARS) and two-photon auto-fluorescence (Conference Presentation)", Proc. SPIE 11219, Visualizing and Quantifying Drug Distribution in Tissue IV, 1121905 (20 April 2020); https://doi.org/10.1117/12.2542701
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KEYWORDS
Skin
In vivo imaging
CARS tomography
Absorption
Molecules
Auto-fluorescence imaging
Diffusion
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