Characterization of retinal changes in a mouse model of Alzheimer’s disease using multi-contrast optical coherence tomography (Conference Presentation)

Bernhard Baumann; Danielle J. Harper; Antonia Lichtenegger; Johanna Gesperger; Tanja Himmel; Martina Muck; Conrad W. Merkle; Pablo Eugui; Stefan Kummer; Adelheid Woehrer; Martin Glösmann; Marco Augustin

doi:10.1117/12.2548412

9 March 2020 Characterization of retinal changes in a mouse model of Alzheimer’s disease using multi-contrast optical coherence tomography (Conference Presentation)

Bernhard Baumann, Danielle J. Harper, Antonia Lichtenegger, Johanna Gesperger, Tanja Himmel, Martina Muck, Conrad W. Merkle, Pablo Eugui, Stefan Kummer, Adelheid Woehrer, Martin Glösmann, Marco Augustin

Author Affiliations +

Proceedings Volume 11218, Ophthalmic Technologies XXX; 112181C (2020) https://doi.org/10.1117/12.2548412
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Recent Alzheimer’s disease (AD) studies have focused on retinal analysis, as the retina is the only part of the central nervous system which can be imaged non-invasively by optical methods. The appearance of the retina of the APP/PS1 mouse model of AD was therefore evaluated by a custom-built multi-contrast optical coherence tomography (OCT) system. By visualizing retinal changes over a range of ages in intensity-, polarization- and motion-based contrast modes simultaneously, observations in the retina were documented and compared to both retinal whole-mounts and conventional histological sections. The data was also correlated to the cortical amyloid beta plaque load.

Conference Presentation

Citation Download Citation

Bernhard Baumann, Danielle J. Harper, Antonia Lichtenegger, Johanna Gesperger, Tanja Himmel, Martina Muck, Conrad W. Merkle, Pablo Eugui, Stefan Kummer, Adelheid Woehrer, Martin Glösmann, and Marco Augustin "Characterization of retinal changes in a mouse model of Alzheimer’s disease using multi-contrast optical coherence tomography (Conference Presentation)", Proc. SPIE 11218, Ophthalmic Technologies XXX, 112181C (9 March 2020); https://doi.org/10.1117/12.2548412

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Optical coherence tomography

Alzheimer's disease

Mouse models

Retina

In vivo imaging

Brain

Genetics

Show All Keywords

Keywords/Phrases

Search In:

Publication Years