Capillary refill: a technique for obtaining histology-grade OCT angiography maps of human dermal vasculature in vivo (Conference Presentation)

Michael Evers; Malte Casper; Garuna Kositratna; Josh Glahn; Weeranut Phothong; Tuanlian Luo; Dieter Manstein

doi:10.1117/12.2545086

6 March 2020 Capillary refill: a technique for obtaining histology-grade OCT angiography maps of human dermal vasculature in vivo (Conference Presentation)

Michael Evers, Malte Casper, Garuna Kositratna, Josh Glahn, Weeranut Phothong, Tuanlian Luo, Dieter Manstein

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Proceedings Volume 11211, Photonics in Dermatology and Plastic Surgery 2020; 112110T (2020) https://doi.org/10.1117/12.2545086
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Optical coherence tomography angiography (OCTA) provides in-vivo images of microvasculature. In skin it often represents a dynamic perfusion state without depicting the actual extent of the vascular network. Here, we present the capillary refill method for obtaining a more accurate anatomic representation of surface capillary networks in human skin using OCTA. OCTA images were captured at baseline displaying ambient capillary perfusion and after compression and release of the skin representing the network of existing capillaries at full capacity. This method provides mapping of cutaneous capillary networks independent of ambient perfusion comparable to histological analysis of biopsies on identical skin sites.

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Michael Evers, Malte Casper, Garuna Kositratna, Josh Glahn, Weeranut Phothong, Tuanlian Luo, and Dieter Manstein "Capillary refill: a technique for obtaining histology-grade OCT angiography maps of human dermal vasculature in vivo (Conference Presentation)", Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110T (6 March 2020); https://doi.org/10.1117/12.2545086

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KEYWORDS

Capillaries

Skin

Angiography

In vivo imaging

Optical coherence tomography

Biopsy

Diagnostics

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