Biosensor platforms of the polarization-dependent metamaterials for the detection of cancer-cell concentration

Z. Zhang; M. Yang; Lan-Ju Liang; X. Yan; Y. Lu; D. Wei; J. Yao

doi:10.1117/12.2534423

18 November 2019 Biosensor platforms of the polarization-dependent metamaterials for the detection of cancer-cell concentration

Z. Zhang, M. Yang, Lan-Ju Liang, X. Yan, Y. Lu, D. Wei, J. Yao

Author Affiliations +

Proceedings Volume 11196, Infrared, Millimeter-Wave, and Terahertz Technologies VI; 111960X (2019) https://doi.org/10.1117/12.2534423
Event: SPIE/COS Photonics Asia, 2019, Hangzhou, China

Abstract

The rapid detection of cancer cells is crucial for clinical diagnosis in biomedical field. The traditional flow cytometry (FC) in visible band, a fluorescence-labelling detection, gives rise to the complicated sample preparation and the irrecoverable antibody consumption; it blocks the development toward a convenient detection platform with fast, inexpensive and non-labelling. Here, a specifically designed metamaterial based on split ring resonators (SRRs) is proposed. Such metamaterial operating in terahertz (THz) range exhibits polarization-dependent resonances, which are observed both in experiments and simulations. Additionally, the biosensing property of the metamaterial is investigated. On metamaterial surfaces, the lung cancer cells A549 are cultured. Under the irradiation of x-polarized THz waves, it is found that for the cell concentrations from 1×10⁵ cells/ml to 5×10⁵ cells/ml, the maximum frequency shift Δf (the frequency difference between measured sample and bare one) at 2.24 THz increases from 15 GHz to 137 GHz, respectively. Such results also imply that a larger cell concentration leads to a higher frequency shift. Subsequently, the samples are further measured at different polarization angles. The results show that for cell concentration of 5×10⁵ cells/ml, the Δf exhibits the same value of 130 GHz when polarization angle equals 30° and 150°, and 15 GHz when polarization angle equals 60° and 120°. Our proposed metamaterial may supply a potential biosensing method for the detection of cancer cells, exhibiting a new insight toward the cancer cell biosensing with certain information of polarization response.

Citation Download Citation

Z. Zhang, M. Yang, Lan-Ju Liang, X. Yan, Y. Lu, D. Wei, and J. Yao "Biosensor platforms of the polarization-dependent metamaterials for the detection of cancer-cell concentration", Proc. SPIE 11196, Infrared, Millimeter-Wave, and Terahertz Technologies VI, 111960X (18 November 2019); https://doi.org/10.1117/12.2534423

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KEYWORDS

Metamaterials

Biosensors

Polarization

Biosensing

Terahertz radiation

Cancer

Biomedical optics

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