Optofluidic chromatography: label-free sorting of exosomes with plasmonic microlenses

Xiangchao Zhu; Ahmet Cicek; Yixiang Li; Ahmet Ali Yanik

doi:10.1117/12.2529723

9 September 2019 Optofluidic chromatography: label-free sorting of exosomes with plasmonic microlenses

Xiangchao Zhu, Ahmet Cicek, Yixiang Li, Ahmet Ali Yanik

Proceedings Volume 11083, Optical Trapping and Optical Micromanipulation XVI; 1108339 (2019) https://doi.org/10.1117/12.2529723
Event: SPIE Nanoscience + Engineering, 2019, San Diego, California, United States

Abstract

We introduce a subwavelength thick (~ 200 nm) plasmofluidic microlens that effortlessly achieves objective-free focusing and self-alignment of opposing optical scattering and fluidic drag forces for selective separation of exosome size bioparticles. Our optofluidic microlens provides a self-collimating mechanism for particle trajectories with a spatial dispersion that is inherently minimized by the optical gradient and radial fluidic drag forces. We demonstrate that this facile platform facilitates complete separation of small size bioparticles (i.e., exosomes) from a heterogenous mixture through negative depletion and provides a robust selective separation capability based on differences in chemical composition (refractive index). Unlike existing optical chromatography techniques that require complicated instrumentation (lasers, objectives and precise alignment stages), our platform open up the possibility of multiplexed and high-throughput sorting of nanoparticles on a chip.

Citation Download Citation

Xiangchao Zhu, Ahmet Cicek, Yixiang Li, and Ahmet Ali Yanik "Optofluidic chromatography: label-free sorting of exosomes with plasmonic microlenses", Proc. SPIE 11083, Optical Trapping and Optical Micromanipulation XVI, 1108339 (9 September 2019); https://doi.org/10.1117/12.2529723

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