Simulations for modeling the photothermal response of nerve tissue

Merve Turker; Serhat Tozburun

doi:10.1117/12.2527204

22 July 2019 Simulations for modeling the photothermal response of nerve tissue

Merve Turker, Serhat Tozburun

Proceedings Volume 11079, Medical Laser Applications and Laser-Tissue Interactions IX; 110791N (2019) https://doi.org/10.1117/12.2527204
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Optical nerve stimulation (ONS) using infrared laser radiation is a technique developing as a potential alternative to electrical stimulation of nerve tissue. This preliminary study proposes and explores a computer simulation tool for numerically optimizing laser and surface scanning parameters including laser power and surface scanning speed to be used in laser scanning subsurface ONS. This tool consisted of three parts, including the Monte Carlo simulations for generating laser energy distribution in the tissue sample, the laser-scanning model by moving the heat source at the surface, and the thermal transfer simulations to calculate the tissue temperature. In the simulations, the laser wavelength of 1490 nm was used and the surface scan was performed on both x and y axes. In addition, the tissue model was constructed in such a way that the nerve tissue extends over the y-axis. As a result of calculations, the nerve tissue temperature map was produced as a function of laser power and surface scanning speed. According to the temperature map, the optimal laser power to reach the nerve temperature at 43 °C was estimated to be 15 mW at the scanning speeds of 1.2 mm/s in the x-axis and 1.0 mm/s in the y-axis. With further development this simulation tool may hold promise in the development of an optical stimulus device.

Citation Download Citation

Merve Turker and Serhat Tozburun "Simulations for modeling the photothermal response of nerve tissue", Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, 110791N (22 July 2019); https://doi.org/10.1117/12.2527204

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available