Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

Marcel Schubert; Lewis Woolfson; Isla R. M. Barnard; Andrew Morton; Becky Casement; Gavin B. Robertson; Gareth B. Miles; Samantha J. Pitt; Carl S. Tucker; Malte C. Gather

doi:10.1117/12.2526955

22 July 2019 Microlaser-based contractility sensing in single cardiomyocytes and whole hearts

Marcel Schubert, Lewis Woolfson, Isla R. M. Barnard, Andrew Morton, Becky Casement, Gavin B. Robertson, Gareth B. Miles, Samantha J. Pitt, Carl S. Tucker, Malte C. Gather

Author Affiliations +

Proceedings Volume 11075, Novel Biophotonics Techniques and Applications V; 110750C (2019) https://doi.org/10.1117/12.2526955
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Microscopic whispering gallery mode lasers detect minute changes in cellular refractive index inside individual cardiac cells and in live zebrafish. We show that these signals encode cardiac contractility that can be used for intravital sensing.

Citation Download Citation

Marcel Schubert, Lewis Woolfson, Isla R. M. Barnard, Andrew Morton, Becky Casement, Gavin B. Robertson, Gareth B. Miles, Samantha J. Pitt, Carl S. Tucker, and Malte C. Gather "Microlaser-based contractility sensing in single cardiomyocytes and whole hearts", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110750C (22 July 2019); https://doi.org/10.1117/12.2526955

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