Alzheimer’s disease: label-free fluorescence shows increases in indoleamine 2,3-dioxygenase (IDO) or tryptophan 2,3-dioxygenase (TDO) activity in affected areas of the brain

Laura A. Sordillo; Lin Zhang; Peter P. Sordillo; Robert R. Alfano

doi:10.1117/12.2513384

4 March 2019 Alzheimer’s disease: label-free fluorescence shows increases in indoleamine 2,3-dioxygenase (IDO) or tryptophan 2,3-dioxygenase (TDO) activity in affected areas of the brain

Laura A. Sordillo, Lin Zhang, Peter P. Sordillo, Robert R. Alfano

Author Affiliations +

Proceedings Volume 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 108731C (2019) https://doi.org/10.1117/12.2513384
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Abnormal tryptophan metabolism is a major factor in Alzheimer’s disease. Thus, understanding the role of indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO), enzymes that causes increased tryptophan metabolism down the kynurenine pathway, is crucial. Tissue samples from the hippocampus, Brodmann’s area 9 (BA 9) and Brodmann’s area 17 (BA 17) from Alzheimer’s patients, from patients with psychosis and from age-matched, normal controls (total of 47 samples) were studied. An update on the optical properties of Alzheimer’s tissues, utilizing tryptophan/kynurenine ratios, is reported. Ratios of tryptophan/kynurenine were decreased in the hippocampus and BA 9 in patients with Alzheimer’s, consistent with increased neuroinflammation and IDO and/or TDO activity in these areas.

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Laura A. Sordillo, Lin Zhang, Peter P. Sordillo, and Robert R. Alfano "Alzheimer’s disease: label-free fluorescence shows increases in indoleamine 2,3-dioxygenase (IDO) or tryptophan 2,3-dioxygenase (TDO) activity in affected areas of the brain", Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 108731C (4 March 2019); https://doi.org/10.1117/12.2513384

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