Validation of Dosie combined Monte Carlo and photokinetic simulations for the analysis of HPPH-mediated photodynamic therapy on mice

Karl Beeson; Evgueni Parilov; Mary Potasek

doi:10.1117/12.2510686

28 February 2019 Validation of Dosie combined Monte Carlo and photokinetic simulations for the analysis of HPPH-mediated photodynamic therapy on mice

Karl Beeson, Evgueni Parilov, Mary Potasek

Author Affiliations +

Proceedings Volume 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII; 108600N (2019) https://doi.org/10.1117/12.2510686
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

We compare previously reported 2-(1-hexyloxyethyl)-2-divinyl pyropheophorbide (HPPH) mediated photodynamic therapy (PDT) experimental results for singlet oxygen dose on mice with simulations using a new, integrated, hardware and software device, Dosie^TM, that calculates light transport and photokinetics for PDT. The two sets of results are consistent and validate the use of the device simulations to predict HPPH-mediated PDT results on mice animal studies.

Conference Presentation

Citation Download Citation

Karl Beeson, Evgueni Parilov, and Mary Potasek "Validation of Dosie combined Monte Carlo and photokinetic simulations for the analysis of HPPH-mediated photodynamic therapy on mice", Proc. SPIE 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, 108600N (28 February 2019); https://doi.org/10.1117/12.2510686

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