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We compare previously reported 2-(1-hexyloxyethyl)-2-divinyl pyropheophorbide (HPPH) mediated photodynamic therapy (PDT) experimental results for singlet oxygen dose on mice with simulations using a new, integrated, hardware and software device, DosieTM, that calculates light transport and photokinetics for PDT. The two sets of results are consistent and validate the use of the device simulations to predict HPPH-mediated PDT results on mice animal studies.
Karl Beeson,Evgueni Parilov, andMary Potasek
"Validation of Dosie combined Monte Carlo and photokinetic simulations for the analysis of HPPH-mediated photodynamic therapy on mice", Proc. SPIE 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, 108600N (28 February 2019); https://doi.org/10.1117/12.2510686
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Karl Beeson, Evgueni Parilov, Mary Potasek, "Validation of Dosie combined Monte Carlo and photokinetic simulations for the analysis of HPPH-mediated photodynamic therapy on mice," Proc. SPIE 10860, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVIII, 108600N (28 February 2019); https://doi.org/10.1117/12.2510686