Digital polarization-holographic 3D reconstruction of the polycrystalline structure of blood films in the diagnosis of breast cancer

Yu. A. Ushenko; A. V. Syvokorovskaya; M. P. Gorsky; Yu. Ya. Tomka; O. Bakun; D. Kvasnuyk; L. Yu. Kushnerik; S. Golub; R. Besaga

doi:10.1117/12.2320540

5 September 2018 Digital polarization-holographic 3D reconstruction of the polycrystalline structure of blood films in the diagnosis of breast cancer

Yu. A. Ushenko, A. V. Syvokorovskaya, M. P. Gorsky, Yu. Ya. Tomka, O. Bakun, D. Kvasnuyk, L. Yu. Kushnerik, S. Golub, R. Besaga

Author Affiliations +

Proceedings Volume 10728, Biosensing and Nanomedicine XI; 107280S (2018) https://doi.org/10.1117/12.2320540
Event: SPIE Nanoscience + Engineering, 2018, San Diego, California, United States

Abstract

An optical model of the polycrystalline structure of the human blood film is proposed as a superposition of completely polarized and depolarized components. Analytical algorithms for describing the polarization manifestations of such components are found. A new technique for laser sounding of blood films and detection of polarization-inhomogeneous fields by means of variations in the states of polarization of the reference wave is developed. The algorithm of digital holographic reconstruction of distributions of complex amplitudes of the polarization-inhomogeneous object field of polycrystalline films of blood is used. Layered maps of the distribution of azimuth and ellipticity of polarization of the object field of polycrystalline films of blood were obtained and analyzed. 3D distributions of the linear and circular birefringence and dichroism of such films are determined. Sensitivity, specificity and balanced accuracy of the method of digital polarization-holographic 3D reconstruction of the polycrystalline structure of blood films are determined. Statistical analysis of polarization maps of the polycrystalline structure of blood films revealed objective criteria for the diagnosis of breast cancer.

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Yu. A. Ushenko, A. V. Syvokorovskaya, M. P. Gorsky, Yu. Ya. Tomka, O. Bakun, D. Kvasnuyk, L. Yu. Kushnerik, S. Golub, and R. Besaga "Digital polarization-holographic 3D reconstruction of the polycrystalline structure of blood films in the diagnosis of breast cancer", Proc. SPIE 10728, Biosensing and Nanomedicine XI, 107280S (5 September 2018); https://doi.org/10.1117/12.2320540

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