Photodynamic Action Of Benzochlorins

Alan R. Morgan; Greta M. Garbo; Ashraf Rampersaud; Dimitris Skalkos; Rick W. Keck; Steven H. Selman

doi:10.1117/12.978015

13 June 1989 Photodynamic Action Of Benzochlorins

Alan R. Morgan, Greta M. Garbo, Ashraf Rampersaud, Dimitris Skalkos, Rick W. Keck, Steven H. Selman

Proceedings Volume 1065, Photodynamic Therapy: Mechanisms; (1989) https://doi.org/10.1117/12.978015
Event: OE/LASE '89, 1989, Los Angeles, CA, United States

Abstract

A series of benzochlorins have been prepared and tested for tumoricidal activity using the FANFT-induced rat bladder tumor model. Results indicate that these chlorin derivatives, in combination with red light, can cause significant tumor regression at doses as low as 0.5 - 1.0 mg/kg body weight. This compares favorably with other sensitizers tested in the same model and suggests that further studies on the effectiveness of benzochlorins in photodynamic therapy be performed.

Citation Download Citation

Alan R. Morgan, Greta M. Garbo, Ashraf Rampersaud, Dimitris Skalkos, Rick W. Keck, and Steven H. Selman "Photodynamic Action Of Benzochlorins", Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); https://doi.org/10.1117/12.978015

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