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Autofluorescence spectroscopy offer noninvasive and promising tools for the detection
of alternations biochemical compositions of tissues and cells, in presence of disease. They have
the added advantage of being highly objective due to the fact that diagnostic evaluation is by
statistical methods, eliminating errors from lack of experience, fatigue factor, and subjectivity of
visual perceptions. The present research work involves in designing and assembling of a low cost,
miniature oral cancer screening device with for routine clinical applications. A miniature system
was designed and assembled with much smaller and cost-effective components like compact light
source and miniature spectrometer, in a hand-held unit configuration. The performance of the
system was evaluated using animal -mouse- SCC model. The current system can be used in handheld
operation, which makes it very useful for many applications like, screening of squamous cell
carcinoma susceptible population.
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