Probing mechanobiology with laser-induced shockwaves

Christopher Carmona; Daryl C. Preece; Veronica Gomez-Godinez; Linda Z. Shi; Michael W. Berns

doi:10.1117/12.2274563

25 August 2017 Probing mechanobiology with laser-induced shockwaves

Christopher Carmona, Daryl C. Preece, Veronica Gomez-Godinez, Linda Z. Shi, Michael W. Berns

Proceedings Volume 10347, Optical Trapping and Optical Micromanipulation XIV; 103470D (2017) https://doi.org/10.1117/12.2274563
Event: SPIE Nanoscience + Engineering, 2017, San Diego, California, United States

Abstract

Traumatic Brain Injury (TBI) occurs when an external force injures the brain. While clinical outcomes of TBI can vary widely in severity, few mechanisms of neurodegeneration following TBI have been identified for treatment. We propose a model for studying TBI using laser-induced shockwaves (LISs). An optical system was developed that allows single cells to be studied in response to LISs. Our system utilizes an optically-coupled force measurement component that allows for the visualization of shockwave dynamics. Here, the force measurement system is characterized by imaging stages over the period of violent expansion and collapse of microbubbles responsible for shockwave generation.

Citation Download Citation

Christopher Carmona, Daryl C. Preece, Veronica Gomez-Godinez, Linda Z. Shi, and Michael W. Berns "Probing mechanobiology with laser-induced shockwaves", Proc. SPIE 10347, Optical Trapping and Optical Micromanipulation XIV, 103470D (25 August 2017); https://doi.org/10.1117/12.2274563

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