Studies of photosensitizers from the phthalocyanine family in the perspective of two-photon photodynamic therapy

Michel Fournier

doi:10.1117/12.2283912

29 August 2017 Studies of photosensitizers from the phthalocyanine family in the perspective of two-photon photodynamic therapy

Michel Fournier

Author Affiliations +

Proceedings Volume 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging; 1031338 (2017) https://doi.org/10.1117/12.2283912
Event: Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 2002, Ottawa, Ontario, Canada

Abstract

Photodynamic therapy (PDT) of cancer is a treatment with strengths and weaknesses. Amongst the latter is the need for the presence of oxygen for the photodynamic effect to occur. It is a known fact that singlet oxygen, generated from the first triplet excited state (T1) of the photosensitizer, is responsible for the lethal photodynamic effect [1, 2, 3, 4]. The problem lies in the lack of oxygen in the core of a tumor. It seems that the excited triplet state energy of the photosensitizers currently in use in PDT lies below the threshold of a lethal anoxic chemical reaction.

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Michel Fournier "Studies of photosensitizers from the phthalocyanine family in the perspective of two-photon photodynamic therapy", Proc. SPIE 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 1031338 (29 August 2017); https://doi.org/10.1117/12.2283912

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