ALA-induced protoporphyrin IX flurokinetics in dermatological disease states monitored by surface-detected fluorescence

Albane Sibourd-Baudry

doi:10.1117/12.2283897

29 August 2017 ALA-induced protoporphyrin IX flurokinetics in dermatological disease states monitored by surface-detected fluorescence

Albane Sibourd-Baudry

Author Affiliations +

Proceedings Volume 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging; 103132T (2017) https://doi.org/10.1117/12.2283897
Event: Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 2002, Ottawa, Ontario, Canada

Abstract

Photodynamic therapy (PDT) is a relatively new methodology currently being investigated for use in the treatment of cancerous or abnormal tissue. The principle of PDT relies on a photosensitizer that is administered to the patient, then photoexcited to induce a cytotoxic reaction. To be a useful drug for PDT, a photosensitizer should show specific properties. These include a preferential accumulation in abnormal tissue compared to normal tissue, a fast clearance time, a strong absorption in the red or near infrared region of the electromagnetic spectrum, and finally a toxicity in the presence of light but harmless otherwise.

Citation Download Citation

Albane Sibourd-Baudry "ALA-induced protoporphyrin IX flurokinetics in dermatological disease states monitored by surface-detected fluorescence", Proc. SPIE 10313, Opto-Canada: SPIE Regional Meeting on Optoelectronics, Photonics, and Imaging, 103132T (29 August 2017); https://doi.org/10.1117/12.2283897

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