Speckle variance full-field optical coherence microscopy for high-resolution microvasculature mapping

Jonas Ogien; Arnaud Dubois

doi:10.1117/12.2254836

17 February 2017 Speckle variance full-field optical coherence microscopy for high-resolution microvasculature mapping

Jonas Ogien, Arnaud Dubois

Proceedings Volume 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI; 100532O (2017) https://doi.org/10.1117/12.2254836
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

This work reports on the feasibility of dynamic imaging using conventional reflectivity-based tomographic images obtained with full-field optical coherence microscopy (FF-OCM). Implementation of speckle variance for flow mapping with an imaging rate of 180 Hz is demonstrated by mapping 20% intralipid flowing into 100-μm-diameter microcapillary tubes at speeds up to ~ 50 mm/s. This constitutes a significant advance in high-resolution, real-time microvasculature mapping, using FF-OCM. The acquisition scheme in FF-OCM is particularly appropriate for en face visualization of the microvasculature, as FF-OCM directly acquires en face tomographic images unlike conventional OCT which usually requires reslicing of a three-dimensional data set to get en face images.

Citation Download Citation

Jonas Ogien and Arnaud Dubois "Speckle variance full-field optical coherence microscopy for high-resolution microvasculature mapping", Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI, 100532O (17 February 2017); https://doi.org/10.1117/12.2254836

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